Rubicon News

News releases related to our efforts to develop our two platform technologies are shown below.

Releases are listed in chronological order and are archived by year and category.  Click on the items below to read the full announcement and use the navigation tools to search for previous releases in our archives.

Recent Announcements

January 12th, 2018: Rubicon Announces NEI Grant Award

Sept 25th, 2017: Rubicon Announces Publication in JACC

June 14th, 2017: Rubicon to Exhibit at BIO 2017

Jan 25th, 2017: Rubicon Signs Agreement with Foothill Scientific

Oct 12th, 2016: Rubicon Presents at Bio-Investor Forum

Sept 16th, 2016: Rubicon Announces Heat Shock Protein Publication

Rubicon’s technologies have been published in the peer-reviewed journals listed below.

         Targeted Heat Shock Proteins (Fv-Hsp70)

  • Tanimoto,T., Parseghian,M.H., Nakahara,T., Kawai,H., Narula,N., Kim,D., Nishimura,R., Weisbart,R.H., Chan,G., Richieri,R.A., Haider,N., Chaudhry,F., Reynolds,G.T., Billimek,J., Blankenberg,F.G., Sengupta,P.P., Petrov,A.D., Akasaka,T., Strauss,H.W., and Narula,J. (2017) • Cardioprotective Effects of HSP72 Administration on Ischemia-Reperfusion Injury.  J. Am. Coll. Cardiol. 70 (12): 1479-1492. For abstract, click here:
  • Parseghian,M.H., Hobson,S.T., and Richieri,R.A. (2016) • Targeted heat shock protein 72 for pulmonary cytoprotection. Ann. N. Y. Acad. Sci. 1374 (1): 78-85.  For abstract, click here: doi: 10.1111/nyas.13059
  • Weisbart, R.H., Chan, G., Jordaan, G., Noble, P.W., Liu, Y., Glazer, P.M., Nishimura, R.N., and Hansen, J.E. (2015) • DNA-dependent targeting of cell nuclei by a lupus autoantibody. Sci. Rep. 5: 12022.  For full article, click here: doi: 10.1038/srep12022
  • Zhan, X., Ander, B.P., Liao, I.H., Hansen, J.E., Kim, C., Clements, D., Weisbart, R.H., Nishimura, R.N., and Sharp, F.R. (2010) • Recombinant Fv-Hsp70 protein mediates neuroprotection after focal cerebral ischemia in rats. Stroke 41 (3): 538-543.  For full article, click here: doi: 10.1161/STROKEAHA.109.572537
  • Hansen, J.E., Tse, C.M., Chan, G., Heinze, E.R., Nishimura, R.N., and Weisbart, R.H. (2007) • Intranuclear protein transduction through a nucleoside salvage pathway. J Biol. Chem. 282 (29): 20790-20793.  For full article, click here: PMID: 17525162
  • Hansen, J.E., Sohn, W., Kim, C., Chang, S.S., Huang, N.C., Santos, D.G., Chan, G., Weisbart, R.H., and Nishimura, R.N. (2006) • Antibody-mediated Hsp70 protein therapy. Brain Res. 1088 (1): 187-196.  For abstract, click here: PMID: 16630585
  • Weisbart, R.H., Baldwin, R., Huh, B., Zack, D.J., and Nishimura, R. (2000) • Novel protein transfection of primary rat cortical neurons using an antibody that penetrates living cells. J Immunol. 164 (11): 6020-6026.  For full article, click here: doi: 10.4049/jimmunol.164.11.6020
  • Spertini, F., Leimgruber, A., Morel, B., Khazaeli, M.B., Yamamoto, K., Dayer, J.M., Weisbart, R.H., and Lee, M.L. (1999) • Idiotypic vaccination with a murine anti-dsDNA antibody: phase I study in patients with nonactive systemic lupus erythematosus with nephritis. J Rheumatol. 26 (12): 2602-2608.  For abstract, click here: PMID: 10606369
  • Weisbart, R.H., Stempniak, M., Harris, S., Zack, D.J., and Ferreri, K. (1998) • An autoantibody is modified for use as a delivery system to target the cell nucleus: therapeutic implications. J Autoimmun. 11 (5): 539-546.  For abstract, click here: PMID: 9802941

         Annexin A5 Immunotherapeutics

  • Ungethum, L., Kenis, H., Nicolaes, G.A., Autin, L., Stoilova-McPhie, S., and Reutelingsperger, C.P. (2011) • Engineered annexin A5 variants have impaired cell entry for molecular imaging of apoptosis using pretargeting strategies. J Biol Chem. 286 (3): 1903-1910.  For full article, click here: doi: 10.1074/jbc.M110.163527
  • Schutters, K., and Reutelingsperger, C. (2010) • Phosphatidylserine targeting for diagnosis and treatment of human diseases. Apoptosis 15 (9): 1072-1082.  For full article, click here: doi: 10.1007/s10495-010-0503-y
  • Kenis, H., and Reutelingsperger, C. (2009) • Targeting phosphatidylserine in anti-cancer therapy. Curr Pharm Design 15: 2719-2723.  For abstract, click here: doi: 10.2174/138161209788923903
  • Ran, S., Downes, A., and Thorpe, P.E. (2002) • Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res.62 6132-6140.  For full article, click here: PMID: 12414638
  • Reutelingsperger, C.P., Hornstra, G., and Hemker, H.C. (1985) • Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord. Eur. J Biochem. 151 (3): 625-629.  This paper describes the discovery of Annexin A5 (also known as Annexin V).  For abstract, click here: doi: 10.1111/j.1432-1033.1985.tb09150.x